Quality of Life in Thalassemia Patients After Unrelated Hematopoietic Stem Cell Transplantation

60 Journal of Medicine and The Person, June 2008, vol.6, number 2: 60-64 I NVITED PAPER eccentric of life in thalassaemia patients afterwards unrelated haematopoietic melodic theme jail cell transplanting Qualità della vita in pazienti talassemici dopo trapianto non correlato di cellule staminali emopoietiche Caocci Giovanni1, Pisu Salvatore2, La Nasa Giorgio1 1 Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, Cattedra di Ematologia, Università di Cagliari, Cagliari, Italy. 2 Cattedra di Medicina Legale, Università di Cagliari, Cagliari, Italy Abstract thalassaemia major is a chronic, progressive hemoglobin disorder requiring life-long blood transfusion and iron chelation therapy for survival. Extensive ongoing medical c be in this pathology may have a considerable shock on the physical, psychosocial well-being and quality of life (QoL) of patients and their families. Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the e xclusively cure in stock(predicate) for thalassemia. Unfortunately, only a substantial minority of patients have an HLA harmonious bestower within the family. More than 70 percent of patients need to search for an unrelated compatible sponsor in voluntary conferrer registries worldwide. The transplantation-related mortality risk of unrelated HSCT in adult thalassemia patients has been estimated to be about 30%. For this reason, patients without a family donor be faced with the difficult choice between accepting the granulose risks of radical treatment or putting aside their hopes of retrieval and continuing regular transfusion and iron chelation therapy. This complex ending-making mapping raises several social, psychological and ethical problems. The central ethical hit do of HSCT in a non-malignant disease can be close in in terms of a negate between cardinal fundamental principles of medical ethics: non-maleficence and beneficence; the question arises as to who will be responsible for the decision and wh! at criteria can be used to strike a elegant balance...If you want to posture a full essay, order it on our website: OrderCustomPaper.com

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